- FDA-approved HBOT has a strong safety record; serious complications are rare when proper protocols are followed.
- The most common side effect is mild ear discomfort – manageable with simple pressure-equalization techniques.
- Not all hyperbaric chambers are equal; FDA clearance is the baseline standard for safe use.
- Certain medical conditions and medications may affect HBOT suitability.
- A prescription is required to purchase an OxyHealth chamber through Airpuria.

Is HBOT Safe? A Science-Backed Guide to Hyperbaric Oxygen Therapy Safety in the US
Hyperbaric oxygen therapy (HBOT) has a strong clinical safety record – but whether it's safe for you depends on the equipment used, the condition being treated, and the protocols in place. When administered using FDA-cleared chambers for approved indications, HBOT is considered safe and well-tolerated by most people, with side effects that are typically mild and self-limiting.
Key HBOT Safety Insights You Need to Know
What is HBOT?
Hyperbaric oxygen therapy involves breathing 100% oxygen while resting in a pressurized chamber. Pressure inside the chamber is increased up to 2.5 times normal, allowing your lungs to absorb more oxygen and deliver it more effectively to your organs and tissues. HBOT has been shown to promote wound healing, athletic performance and recovery, anti-aging, and overall wellness.